Publications

Articles

Gaillard PJ. Case Study: to-BBB’s G-Technology^®, getting the best from drug-delivery research with industry-academia partnerships. Therapeutic Delivery 2011, 2(11):1391-1394

Gaillard PJ. Crossing barriers from blood-to-brain and academia-to-industry. Therapeutic Delivery 2010, 1(4):495-500 [PDF]

Gaillard PJ, Visser CC, Appeldoorn CCM, and Rip J. Targeted blood-to-brain drug delivery – 10 key development criteria. Curr Pharm Biotechn, accepted for publication.

Van Weperen W and Gaillard PJ. Enhanced drug delivery to the brain: safe and versatile. ONdrugDelivery 2011, July:3-15 [PDF]

Van Weperen W and Gaillard PJ. Enhanced blood to brain drug delivery. Innovations in Pharmaceutical Technology 2010, December:55-57 [PDF]

Van Weperen W and Gaillard PJ. Beating the barrier. MedLabNews 2010, June:13-15 [PDF]

Gaillard PJ, de Boer AG. 2B-Trans-Technology: targeted delivery across the blood-brain barrier. In, Jain KK (ed) Drug Delivery Systems, Springer/Humana Press, 2008, 161-175.   

De Boer AG, Gaillard PJ. Drug targeting to the brain. Annu Rev Pharmacol Toxicol. 2007, 47: 323-355. [PDF]

De Boer AG, Gaillard PJ. Strategies to improve drug delivery across the blood-brain barrier. Clin Pharmacokinet. 2007, 46(7): 553-576. [full text]

Gaillard PJ, Brink A, de Boer AG. Diphtheria-toxin receptor-targeted brain drug delivery. International Congress Series. 2005, 1277:185-198.

 [full text]

Gaillard PJ, Visser CC, de Boer AG. Targeted delivery across the blood-brain barrier. Exp Opin Drug Deliv. 2005, 2(2): 299-309.

Posters

Gaillard P, Appeldoorn C, Gladdines W, Boogerd W, Beijnen J, Brandsma D, van Tellingen O. Development of glutathione pegylated liposomal doxorubicin (2B3-101) for the treatment of brain metastases from breast cancer. [PDF]
Presented at:
- the 4th European Conference for Clinical Nanomedicine. Basel, Switzerland, 23-25 May, 2011
- the 9th International Conference on Cerebral Vascular Biology. Leiden, the Netherlands, 21-25 June, 2011

Appeldoorn C, Gaillard P, Rip J, Dorland R, vd Pol S, Kooij G, de Vries E, ReijerkerkA. Enhanced brain delivery of liposomal methylprednisolone is beneficial for the treatment of neuroinflammation in EAE. [PDF]
Presented at:
- the 9th International Conference on Cerebral Vascular Biology. Leiden, the Netherlands, 21-25 June, 2011

Rip J, Chen L, van Kregten J, Dorland R, vd Boom B, Appeldoorn C, Muster R, de Boer M, Gaillard P. In vitro evaluation and optimization of drug delivery from glutathione-conjugated PEG coated liposomes. [PDF]
Presented at:
- the 9th International Conference on Cerebral Vascular Biology. Leiden, the Netherlands, 21-25 June, 2011

Van Tellingen O, Brandsma D, Appeldoorn C, Manca F, Rip J, Dorland R, van Kregten J, Boogerd W, Beijnen J, Gaillard P. GSH-conjugation improves efficacy of Doxil against intracranial xenografts.[PDF]
Presented at:
- the 101st Annual Meeting of the American Association for Cancer Research. Washington DC, PA, USA, 17-21 April, 2010
- the 9th congress of the European Association of NeuroOncology. Maastricht, the Netherlands, 16-19 September, 2010

Gaillard P, Rip J, Appeldoorn C, Manca F, van Kregten J, Brandsma D, Boogerd W, Beijnen J, van Tellingen O. GSH-conjugation improves efficacy of doxil in brain cancer models. [PDF]
Presented at:
- the Gordon Research Conference on Barriers of the CNS. New London, NH, USA, 20-25 June, 2010
- the International Liposome Research Days. Vancouver, Canada, 4-8 August, 2010

Rip J, Appeldoorn C, Manca F, Dorland R, van Kregten J, Gaillard P. Receptor-mediated delivery of drugs across the blood-brain barrier. [Abstract]
Presented at:
- the COST workshop on Pharmacology and Toxicology of the Blood-Brain Barrier: State of the Art, Needs for Future Research and Expected Benefits for the EU. Brussels, Belgium. 11-12 February, 2010

Gaillard P, Leyssen P, Appeldoorn C, Dorland R, van Kregten J, Manca F, Neyts. Development of brain-targeted liposomes with antiviral drugs for treating lethal viral encephalitis. [PDF]
Presented at:
- the 8th International Conference on Cerebral Vascular Biology. Sendai, Japan, 28 June – 2 July, 2009
- the 4th International Liposome Society Conference. London, UK, 12-15 December, 2009